Teresita Menini, MD, MS
Professor

Main areas of interest:

  •  Non-enzymatic glycation of proteins and lipoproteins
  • Paraoxonase and cardiovascular disease
  • Ischemia modified albumin and soluble RAGES as markers of stroke
  • Circulating heat shock proteins and psychological stress.

Osteopathic Manipulation Project:

  • Stress reduction using manipulation techniques that modify sympathetic flow

Medical Education

  • Ongoing pilot project where we assess clinical reasoning in second and third year medical students
  • Implementation of ePortfolios in Medical School

Number of Peer Review Publications: 10 at Touro California

Past Intramural Funding:

  • Interaction between advanced glycation end-products of proteins and macrophages. 
    Touro University. -1999 Co-PI. 
  • Interaction between advanced glycation end-products of proteins and macrophages.

Touro University – 2001 – $ 15,700. Co-PI – This was a joint effort together with Dr. Meszaros and Dr. Gugliucci.

  • Circulating heat shock proteins and psychological stress.

Touro University – 2004 – $ 24,000. PI

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Alan Miller, PhD
 Professor

Physiology and Biophysics, University of California at Irvine
PhD and Postdoc in biophysics of ion channels, mostly electrical recordings.

Description:

  • Block of the cardiac potassium channel HERG by a number of pharmaceutical agents can cause Long QT Syndrome. In rare cases Long QT can degenerate into ventricular fibrillation which can be lethal. Experiments in my laboratory are designed to elucidate the mechanisms by which a number of different drugs block HERG and cause Long QT syndrome.

Peer reviewed journals related to this project:

  • Barrows et al: Extracellular potassium dependency of block of HERG by quinidine and cisapride is primarily determined by the permeant ion and not by inactivation. Channels 3:4, 240-249 2009

Past Funding:

  • PI NIHR15 7/6/06-6/30/11 Mechanisms of serum electrolyte effects on block of HERG. $150,000, direct costs, $98,350 indirect costs.
  • Intramural Grant Touro University – California - $14,500  7/1/03-7/1/04
  • Effects of Extracellular Electrolytes on Drug Block of the Cardiac Potassium Channel HERG
  • Intramural grant – Touro University – California - $11,208  7/01/01-7/01/02
  • Effects of Extracellular Electrolytes on Cloned Potassium Channels.

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Shin Murakami, PhD
Associate Professor

Research Project(s) descriptions:
Potential collaborative projects include (but not limited to): (1) Invertebrate model of age-related memory impairment and Alzheimer's disease, which is useful for target identification (genes) and drug development for the treatment (R01 submitted); (2) Developing community outreach for K12 students, which is a part of COM strategic planning for community and state service (the goal is to submit R25 Research Education or other grant application).

Number of Peer Reviewed Publications: 37

Past and Pending funding

  • NIH R01 (Pending), Murakami (PI), (2012-2017) AACOM Mini-Grant, Murakami (Collaborator), Binstock J and Junsanto-Bahri T (PIs), (2011).
  • Intramural grant, Touro University-California (2009-2010) NIH Montata INBRE (2008), Selected for Project leader (Withdrawn due to relocation) Gheens Foundation Grant, University of Louisville (2004-2007) Internal Research Initiation Grant, University of Louisville (2007)

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Jean-Marc Schwarz, PhD
Professor of Biochemistry
Website

Research project(s) description

  • Title: "Metabolic impact of fructose restriction in obese children" The goal of this project is to assess the effect of fructose restriction diet on hepatic de novo lipogenesis , liver fat content and triglyceride levels.
  • Title: "De novo lipogenesis in the pathogenesis of non-alcoholic fatty liver disease" The goals of this project are to measure the contribution of de novo hepatic lipogenesis to liver fat content and test the hypothesis that reducing dietary fructose intake will reduce liver fat in patients with steatosis .
  • Title: "Hepatic and extra-hepatic carbohydrate metabolism in non-alcoholic fatty liver disease" The goals of this project are to evaluate the role of glucose fluxes in modulating liver fat content and insulin sensitivity; and the effects of a dietary intervention on hepatic and extrahepatic insulin sensitivity in individuals with steatosis .
  • Title: "Effect of Antiretroviral Drugs and Metabolism" This study looks at the mechanisms by which HIV protease inhibitor drugs affect glucose metabolism by administering drugs to HIV- seronegative controls.
  • Title: "Fatty acid sources of fructose and HFCS-induced postprandial hypertriglyceridemia " High sugar diets are associated with increased incidence of cardiovascular disease and diabetes. We hypothesize that increased plasma TG concentrations after meals lead to the increases of other risk factors, and studies are proposed to investigate the late-night postprandial increase of TG induced by consumption of HFCS and fructose.
  • Title: " Uridine Supplementation, Mitochondrial Function, and Glucose Metabolism in HIV" The major goal of this project is to determine whether supplementation with uridine will improve insulin sensitivity and overall glucose metabolism in HIV-infected patients with evidence of insulin resistance and mitochondrial dysfunction.

Number of Peer Reviewed Publications at Touro: 19

Current funding (at Touro) specify if extra or intramural:

  • 1R01DK089216-01 (Schwarz, Lustig )  7/1/10 -6/30/15 Metabolic impact of fructose restriction in obese children
  • Role: PI (MPI)
  • R01 DK078133 (Schwarz)  9/01/07 – 8/31/12 De Novo Lipogenesis in the Pathogenesis of Non-Alcoholic Fatty Liver Disease Role: PI
  • 1R01HL107256-01 (Havel, Schwarz)  09/01/11-8/31/15 Fatty acid sources of fructose and HFCS-induced postprandial hypertriglyceridemia . Role: PI (MPI)
  • R01 DK066999 ( Grunfeld )  03/01/04-1/31/12 Effect of Antiretroviral Drugs and Metabolism
    Role: Co-I

Past funding

  • 1-08-CR-56 (Schwarz)  01/01/08-12/31/10  1.2 calendar American Diabetes Association  $180,000
  • R21 AT003374 NIH/NCCAM ( Schambelan )  08/01/06-6/30/10
  • Uridine Supplementation, Mitochondrial Function, and Glucose Metabolism in HIV
    Role: Co-I

Pending

  • NIH/NIHLB1 R01, (PI) Lipogenesis , lipoprotein flux and CVD risk: role of meal composition and frequency. Requested 3, 647,000 If funded start 04/01/2012.

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Ted Wong, PhD
Associate Professor of Physiology

Physiology 

  • Physiological Adaptations to Physical Activity (Exercise). Recent studies have examined (1) the differential effects of low versus moderate intensity cycling exercise for normalizing postprandial glycemia and (2) the relative influence of caffeine and exercise on resting metabolic rate measured by indirect calorimetry .

Number of Peer Reviewed Publications: 1

Intramural Grant Award:
  • Touro University-CA, Office of Institutional Research.  "Exercise Intensity and Postprandial Glycemia Control".  2006-2007. T. Wong, PI
  • Touro University-CA, Office of Institutional Research.  "Using Osteopathic Manipulative Medicine to Decrease the Incidence of Acute Mountain Sickness".  2009-2010. Nathalie Garcia-Russell, PI T. Wong, et.al. Co-Investigators.

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Last Updated: 6/23/14