Current Research Studies

The following are ongoing clinical research studies being conducted at the MRC or at affiliated sites by MRC investigators. If you would like to participate in one of our research studies, please e-mail and indicate which study you are interested in. 


Metabolic Effects of Sugar/Aspartame (MESA) Study

In collaboration with UC Davis, the NIH-funded MESA study seeks to determine the effects of excess sugar intake on metabolism when consumed in an energy-balanced diet. Procedures performed at the MRC include stable isotope infusions, body composition measurement by dual-energy X-ray absorptiometry (DXA), and the hyperinsulinemic, euglycemic clamp. 


Cardiovascular Inflammation Reduction Trial (CIRT)

The primary aim of the Cardiovascular Inflammation Reduction Trial (CiRT) is to directly test the inflammatory hypothesis of atherothrombosis by evaluating whether or not low-dose methotrexate will reduce rates of myocardial infarction, stroke, and cardiovascular death among stable coronary artery disease patients with type 2 diabetes or metabolic syndrome.


Reducing Inflammation with Osteopathic Treatment (RIOT)

The aim of the RIOT trial is to determine whether osteopathic manipulative treatment (OMT) will blunt changes in serum cytokines that are markers of inflammation and adipokines in asymptomatic subjects.



This Phase III trial tests if the drug, dulaglutide, is effective and safe for treating type 2 diabetes in children and teens.


Takeda Phase 3 Alogliptin Pediatric Study

The purpose of this study is to evaluate the efficacy and safety of alogliptin when administered as a monotherapy, or when added onto a background of metformin alone, insulin alone, or a combination of metformin and insulin, in 10-17 year olds with type 2 diabetes mellitus.


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